Cytokines and Effector/Regulatory Cells Characterization in the Physiopathology of Cutaneous Lupus Erythematous: A Cross-Sectional Study
Table 3
Cytokine expression and regulatory circulating cells in patients with lupus erythematosus.
HD ()
HSc ()
DLE ()
SCLE ()
CD3+/CD4+/CD161−/IL-22+ cells (%)
Mean ± SEM
2.4 ± 0.1
6.0 ± 0.8
12.4 ± 0.4
10.5 ± 0.3
Median
2.8
5.9
12.1
10.3
Range
1.5–3.0
4.4–8.9
10.2–15.2
9.5–12.5
CD3+/CD4+/CD161+/IL-17A+ cells (%)
Mean ± SEM
2.1 ± 0.1
6.0 ± 0.4
10.3 ± 0.3
5.2 ± 0.4
Median
2.2
6.4
10.3
4.7
Range
1.1–2.8
4.3–6.7
8.5–11.9
3.9–9.0
CD3+/CD4+/CD14−/IL-4+ cells (%)
Mean ± SEM
2.0 ± 0.1
8.4 ± 0.6
6.6 ± 0.3
7.1 ± 0.2
Median
2.1
8.6
6.9
7.3
Range
1.2–2.9
6.2–9.6
4.6–8.8
5.5–8.4
CD3+/CD4+/CD14−/IFN-γ+ cells (%)
Mean ± SEM
1.9 ± 0.2
5.6 ± 0.6
9.0 ± 0.2
7.0 ± 0.2
Median
1.7
6.1
8.7
6.8
Range
1.1–3.0
3.2–6.8
8.0–10.9
6.1–8.4
CD3+/CD4+/CD25/Foxp3+ cells (%)
Mean ± SEM
8.4 ± 0.2
10.1 ± 0.3
8.1 ± 0.2
8.3 ± 0.3
Median
8.5
10.4
8.3
8.5
Range
7.1–9.2
9.5–10.7
5.5–9.3
6.6–9.8
CD19+/CD24/CD38/IL-10+ cells (%)
Mean ± SEM
10.3 ± 0.3
12.1 ± 1.1
12.9 ± 0.4
10.8 ± 0.4
Median
10.0
10.8
13.0
10.3
Range
7.8–12.5
9.8–15.5
10.4–14.8
9.1–13.0
CD123/CD196+/IDO+ cells (%)
Mean ± SEM
18.6 ± 0.4
19.0 ± 0.9
33.2 ± 0.7
23.4 ± 0.7
Median
18.4
18.6
32.3
22.6
Range
15.2–22.4
17.0–21.9
28.5–39.0
20.0–27.1
HD: healthy donors; HSc: hypertrophic scar; DLE: discoid lupus erythematosus; SCLE: subacute cutaneous lupus erythematosus. HD versus HSc: ; HD versus DLE: ; HD versus SCLE: ; HSc versus DLE: ; HSc versus SCLE: ; DLE versus SCLE: .
