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Mediators of Inflammation
Volume 2016, Article ID 7216912, 13 pages
http://dx.doi.org/10.1155/2016/7216912
Research Article

Anti-Inflammatory Effect of Rhapontici Radix Ethanol Extract via Inhibition of NF-κB and MAPK and Induction of HO-1 in Macrophages

Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea

Received 17 March 2016; Accepted 29 June 2016

Academic Editor: Julio Galvez

Copyright © 2016 Yun Hee Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Libby, “Inflammatory mechanisms: the molecular basis of inflammation and disease,” Nutrition Reviews, vol. 65, no. 12, supplement 3, pp. S140–S146, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Y. Wang, C. Yu, Y. Pan et al., “A novel compound C12 inhibits inflammatory cytokine production and protects from inflammatory injury in vivo,” PLoS ONE, vol. 6, no. 9, Article ID e24377, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. M. C. Borges, M. A. R. Vinolo, A. R. Crisma et al., “High-fat diet blunts activation of the nuclear factor-κB signaling pathway in lipopolysaccharide-stimulated peritoneal macrophages of Wistar rats,” Nutrition, vol. 29, no. 2, pp. 443–449, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. M. Jin, S.-J. Suh, J. H. Yang et al., “Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-κB and ERK1/2 inactivation,” Food and Chemical Toxicology, vol. 48, no. 11, pp. 3073–3079, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. E.-S. Lee, H. K. Ju, T. C. Moon et al., “Inhibition of nitric oxide and tumor necrosis factor-α(TNF-α) production by propenone compound through blockade of nuclear factor (NF)-κB activation in cultured murine macrophages,” Biological and Pharmaceutical Bulletin, vol. 27, no. 5, pp. 617–620, 2004. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Aga, J. J. Watters, Z. A. Pfeiffer, G. J. Wiepz, J. A. Sommer, and P. J. Bertics, “Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-κB signaling pathways in murine RAW 264.7 macrophages,” American Journal of Physiology-Cell Physiology, vol. 286, no. 4, pp. C923–C930, 2004. View at Publisher · View at Google Scholar · View at Scopus
  7. J. Shao, T. Liu, Q. R. Xie et al., “Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation,” Journal of Neuroimmunology, vol. 254, no. 1-2, pp. 83–90, 2013. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Taesook, S. C. Myeong, A. Y. Lee et al., “Anti-inflammatory activity of methylene chloride fraction from Glehnia littoralis extract via suppression of NF-κB and mitogen-activated protein kinase activity,” Journal of Pharmacological Sciences, vol. 112, no. 1, pp. 46–55, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. C.-H. Kang, Y. H. Choi, S.-Y. Park, and G.-Y. Kim, “Anti-inflammatory effects of methanol extract of Codium fragile in lipopolysaccharide-stimulated RAW 264.7 cells,” Journal of Medicinal Food, vol. 15, no. 1, pp. 44–50, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. M.-S. Lee, M.-S. Kwon, J.-W. Choi et al., “Anti-inflammatory activities of an ethanol extract of Ecklonia stolonifera in lipopolysaccharide-stimulated RAW 264.7 murine macrophage cells,” Journal of Agricultural and Food Chemistry, vol. 60, no. 36, pp. 9120–9129, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. T. M. Lindström and P. R. Bennett, “The role of nuclear factor kappa B in human labour,” Reproduction, vol. 130, no. 5, pp. 569–581, 2005. View at Publisher · View at Google Scholar · View at Scopus
  12. M. R. Mohamed and G. McFadden, “NFκB inhibitors: strategies from poxviruses,” Cell Cycle, vol. 8, no. 19, pp. 3125–3132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. Barnes and M. Karin, “Nuclear factor-κB—a pivotal transcription factor in chronic inflammatory diseases,” The New England Journal of Medicine, vol. 336, no. 15, pp. 1066–1071, 1997. View at Publisher · View at Google Scholar · View at Scopus
  14. Y.-J. Surh, K.-S. Chun, H.-H. Cha et al., “Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation,” Mutation Research, vol. 480-481, pp. 243–268, 2001. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Tsatsanis, A. Androulidaki, M. Venihaki, and A. N. Margioris, “Signalling networks regulating cyclooxygenase-2,” International Journal of Biochemistry and Cell Biology, vol. 38, no. 10, pp. 1654–1661, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. G.-C. Xie and Z.-J. Duan, “Signal transduction of innate immunity to virus infection,” Bing Du Xue Bao, vol. 28, no. 3, pp. 303–310, 2012. View at Google Scholar · View at Scopus
  17. J. M. Kyriakis and J. Avruch, “Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update,” Physiological Reviews, vol. 92, no. 2, pp. 689–737, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. H. Y. Zhou, E. M. Shin, L. Y. Guo et al., “Anti-inflammatory activity of 4-methoxyhonokiol is a function of the inhibition of iNOS and COX-2 expression in RAW 264.7 macrophages via NF-κB, JNK and p38 MAPK inactivation,” European Journal of Pharmacology, vol. 586, no. 1–3, pp. 340–349, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. K.-T. Ku, Y.-L. Huang, Y.-J. Huang, and W.-F. Chiou, “Miyabenol A inhibits LPS-induced NO production via IKK/IκB inactivation in RAW 264.7 macrophages: possible involvement of the p38 and PI3K pathways,” Journal of Agricultural and Food Chemistry, vol. 56, no. 19, pp. 8911–8918, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. D. W. Gilroy, T. Lawrence, M. Perretti, and A. G. Rossi, “Inflammatory resolution: new opportunities for drug discovery,” Nature Reviews Drug Discovery, vol. 3, no. 5, pp. 401–416, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. S. W. Ryter, J. Alam, and A. M. K. Choi, “Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications,” Physiological Reviews, vol. 86, no. 2, pp. 583–650, 2006. View at Publisher · View at Google Scholar · View at Scopus
  22. H.-J. Choi, O.-H. Kang, P.-S. Park et al., “Mume Fructus water extract inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages,” Journal of Medicinal Food, vol. 10, no. 3, pp. 460–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  23. Q.-S. Wang, Y. Xiang, Y.-L. Cui, K.-M. Lin, and X.-F. Zhang, “Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-κB inactivation,” PLoS ONE, vol. 7, no. 3, Article ID e34122, 2012. View at Publisher · View at Google Scholar · View at Scopus
  24. D. A. Guo and Z. C. Lou, “Separation and quantitative determination of three phytoecdysteroids in Rhaponticum uniflorum by High Performance Liquid Chromatography,” Journal of Chinese Pharmaceutical Sciences, vol. 1, no. 1, pp. 60–66, 1992. View at Google Scholar
  25. Y.-H. Zhang, J.-G. Zhang, J.-M. Xie, G.-L. Cheng, and D.-L. Cheng, “Triterpenes from root of Rhaponticum uniflorum,” Zhongguo Zhongyao Zazhi, vol. 30, no. 23, pp. 1833–1836, 2005. View at Google Scholar · View at Scopus
  26. X. Qiao, J. Han, W.-N. He et al., “Chemical fingerprint of commercial Radix Echinopsis and quantitative analysis of α-terthienyl,” Journal of Separation Science, vol. 33, no. 4-5, pp. 530–538, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. D. W. Hommes, M. P. Peppelenbosch, and S. J. H. van Deventer, “Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets,” Gut, vol. 52, no. 1, pp. 144–151, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. X. Yan, H. Zhao, Y. Guan, Y. Song, and J. Meng, “A study on the effect of ethanol extract of Radix rhapontici on erythrocyte immune function in rats,” African Journal of Traditional, Complementary and Alternative medicines, vol. 10, no. 6, pp. 538–541, 2013. View at Google Scholar · View at Scopus
  29. T. J. Guzik, R. Korbut, and T. Adamek-Guzik, “Nitric oxide and superoxide in inflammation and immune regulation,” Journal of Physiology and Pharmacology, vol. 54, no. 4, pp. 469–487, 2003. View at Google Scholar · View at Scopus
  30. T. Ashino, R. Yamanaka, M. Yamamoto et al., “Negative feedback regulation of lipopolysaccharide-induced inducible nitric oxide synthase gene expression by heme oxygenase-1 induction in macrophages,” Molecular Immunology, vol. 45, no. 7, pp. 2106–2115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. H.-Y. Hsu, L.-C. Chu, K.-F. Hua, and L. K. Chao, “Heme oxygenase-1 mediates the anti-inflammatory effect of curcumin within LPS-stimulated human monocytes,” Journal of Cellular Physiology, vol. 215, no. 3, pp. 603–612, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. N. R. Chapman and N. D. Perkins, “Inhibition of the RelA(p65) NF-κB subunit by Egr-1,” Journal of Biological Chemistry, vol. 275, no. 7, pp. 4719–4725, 2000. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Schinella, S. Aquila, M. Dade et al., “Anti-inflammatory and apoptotic activities of pomolic acid isolated from Cecropia pachystachya,” Planta Medica, vol. 74, no. 3, pp. 215–220, 2008. View at Publisher · View at Google Scholar · View at Scopus