NEMO-Binding Domain Peptide Attenuates Lipopolysaccharide-Induced Acute Lung Injury by Inhibiting the NF-κB Signaling Pathway

Figure 9

Effect of NBD on NOX1 expression, as determined via immunohistochemistry, in the lung tissues of mice with ALI. (a) Representative photographs of NOX1 expression in the lung (original magnification ×200). (A) Control group; (B) model group; (C) N-NBD group; (D) NBD-2 group; (E) NBD-6 group; (F) NBD-10 group. Black arrows indicate the immunohistochemically positive NOX1. (b) IHC staining scores pertaining to NOX1 expression. NOX1 expression levels were increased by LPS administration, and these changes were inhibited by NBD pretreatment in a concentration-dependent manner. Data are expressed as the mean ± SD (n = 6). represents versus control group, < 0.05; represents versus model group, < 0.05; represents versus N-NBD group, < 0.05; represents versus NBD-2 group, < 0.05; represents versus NBD-6 group, < 0.05.

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