Serum Cytokine Profiles in Children with Crohn’s Disease

Table 1

Serum cytokine activation in juvenile CD (median [25th–75th percentile]).

Cytokine; (pg/mL)	Controls ()	Acute patients; ()	Remission patients ()
IL-1b	107,7 [16,4–340,8]	550,0 [192,0–784,3]	832,75 [481,9–1 016,0]
IL-2	2,3 [1,5–3.0]	4,3 [3,2–5,4]	5,5 [4,1–7,7]
IL-5	9,0 [3,5–11,8]	6,4 [3,4–16,0]	8,0 [4,5–15,6]
IL-6	23,5 [17,2–27,3]	51,8 [22,8–67,3]	20,3 [12,9–25,3]
IL-8	1 415,3 [997,1–2 625,4]	2 777,0 [611,0–7 382,5]	4 194,0 [411,9–7 220,9]
IL-12	203,2 [120,3–280,0]	217,5 [137,5–519,5]	225,8 [69,8–286,1]
GM-CSF	30,4 [13,5–38,0]	32,0 [10,2–45,3]	35,3 [21,6–50,0]
IFN-γ	2,5 [1,8–3,2]	3,8 [3,2–4,8]	2,8 [2,2–4,3]
CXCL10	384,9 [265,3–435,4]	3 660,0 [2 809,5–4 457,5]	3 685,5 [2 663,5–5 124,0]
TNF-α	4,6 [3,3–6,2]	8,5 [5,3–12,0]	5,0 [3,4–8,6]
IL-4	8,5 [6,3–9,1]	8,7 [7,4–11,7]	7,1 [6,2–8,4]
IL-10	23,9 [17,6–32,4]	22,0 [16,0–60,0]	11,8 [5,9–20,3]

versus controls (Mann–Whitney test).
versus acute patients (Mann–Whitney test).