Serum Cytokine Profiles in Children with Crohn’s Disease

Table 4

Serum cytokine activation in adult CD (median [25th–75th percentile]).

Cytokine; (pg/mL)	Controls; ()	Acute patients; ()	Remission patients; ()
IL-1b	17.4 [11.3–26.1]	47.1 [32.2–87.2]	53.2 [31.0–98.0]
IL-2	110.0 [92.0–141.0]	102.0 [89.0–131.7]	93.0 [52.5–112.5]
IL-4	45.3 [41.6–77.2]	41.0 [34.8–47.8]	56.8 [45.4–68.9]
IL-5	15.2 [11.2–17.2]	12.8 [11.2–16.4]	14.2 [11.2–22.4]
IL-6	120.3 [110.2–128.3]	177.4 [130.6–296.7]	307.8 [174.0–636.2]
IL-8	207.5 [114.4–289.4]	293.3 [163.5–593.9]	236.3 [153.2–625.5]
IL-10	238.4 [166.4–273.1]	258.3 [196.0–291.3]	167.3 [153.5–180.7]
IL-12	18.0 [18.0–415.2]	475.7 [18.0–1076.5]	487.9 [18.0–1 127.1]
CXCL10	6 910.5 [4 729.3–10 178.0]	21 111.7 [17 153.1–27 546.8]	20 009.8 [18 836.5–25 123.4]
GM-CSF	80.2 [45.0–113.7]	199.2 [70.0–470.0]	120.7 [90.9–494.4]
IFN-γ	2 967.0 [2 344.5–3 675.6]	6 750.4 [4 806.5–11 050.0]	6 846.2 [4 054.3–11 456.4]
TNF-α	179.2 [143.6–196.4]	193.0 [179.0–211.3]	113.3 [76.2–171.0]

versus controls (Mann–Whitney test).
versus acute patients (Mann–Whitney test).