Lack of Proinflammatory Cytokine Interleukin-6 or Tumor Necrosis Factor Receptor-1 Results in a Failure of the Innate Immune Response after Bacterial Meningitis

Table 1

Bacterial titers after pneumococcal meningitis.

Bacterial titer (log CFU/mL)
	Blood	Spleen	Cerebellum
WT	5.4 (4.3/6.75)	5.5 (4.88/6.23)	6 (5.3/6.48)
TNFR1-KO	9.65 (8.35/10.23)	9.65 (8.2/10.23)	7.8 (7/9.75)
IL-6-KO	10.5 (6.74/11.05)	8.7 (7/10.21)	8.74 (7/10.64)
TNFR1-IL-6-KO	7.65 (6.25/8.25)	7.7 (7/8.3)	8.3 (6/10)

Data are presented as median (25th/75th percentile). Please note significantly increased bacterial titers in infected TNFR1-, IL-6-, or TNR1-IL-6-KO compared to infected WT mice ( each group; ; for cerebellum; ; Mann-Whitney test) (CFU, colony-forming units; WT, wild type; and KO, knockout).