Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages

<div>Proposed models demonstrating the mechanism that HSYA inhibits NLRP3 inflammasome activation via directly binding to XO in macrophages. ① HSYA first binds to XO and suppresses the activity of XO upregulated by LPS. ② HSYA then inhibits LPS-induced excessive ROS generation. ③ HSYA suppresses NLRP3 inflammasome activation and thus blocked the mature transformation process of IL-1<i>β</i> and IL-18.</div>

Mediators of Inflammation

fig9

Figure 9

Figure 9: Hydroxysafflor Yellow A Inhibits LPS-Induced NLRP3 Inflammasome Activation via Binding to Xanthine Oxidase in Mouse RAW264.7 Macrophages 