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Mediators of Inflammation
Volume 2016, Article ID 8175898, 8 pages
http://dx.doi.org/10.1155/2016/8175898
Research Article

Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy

1Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan
2Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan
3Division of Pulmonology, Department of Pediatric, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 333, Taiwan
4Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital and Chang Gung University, College of Medicine, Taoyuan 204, Taiwan
5Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Keelung, Keelung 204, Taiwan

Received 21 January 2016; Revised 14 April 2016; Accepted 27 April 2016

Academic Editor: Irving Allen

Copyright © 2016 Sui-Ling Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplement 1. Maternal peripheral blood monocytes were collected and stimulated with TLR ligands to test for the expression of TNF-α, IL-6, and IL-10. Regression analysis was used to determine the relation between maternal blood 25(OH)D concentration and TLR-induced cytokine response as continuous variables. Preliminary result showed no correlation between maternal vitamin D status and cytokine response to TLR ligands in maternal mononuclear cells.

Supplement 2. Cord blood monocytes were collected and stimulated with TLR9 ligand to test for the expression of TNF-α, IL-6, and IL-10. Regression analysis was used to determine the relation between cord 25(OH)D concentration and TLR9 -induced cytokine response. Preliminary result showed no correlation between cord vitamin D status and neonatal TLR9-triggered cytokine response.

  1. Supplementary Material