Maternal Vitamin D Level Is Associated with Viral Toll-Like Receptor Triggered IL-10 Response but Not the Risk of Infectious Diseases in Infancy
Table 2
(a) Association between maternal vitamin D level and Toll-like receptor triggered cytokine response. (b) Association between cord blood 25(OH)D level and Toll-like receptor triggered cytokine response.
(a)
Univariate analysis (95% CI)
p
Multivariate analysis (95% CI)
p
TLR1-2
TNF-α
0.42 (0.44, 1.47)
0.36
0.55 (−0.53, 1.59)
0.30
IL-6
0.35 (−0.85, 0.79)
0.92
0.13 (−0.79, 1.05)
0.79
IL-10
0.04 (−0.79, 0.86)
0.93
0.12 (−0.82, 1.06)
0.76
TLR3
TNF-α
0.15 (−0.64, 0.96)
0.73
0.15 (−0.68, 0.94)
0.93
IL-6
−0.45 (−1.15, 0.33)
0.26
−0.42 (−1.48, 0.54)
0.40
IL-10
−0.85 (−1.45, −0.24)
0.007
−1.05 (−1.70, −0.34)
0.004
TLR4
TNF-α
0.12 (−0.19, 0.50)
0.43
0.08 (−0.28, 0.44)
0.44
IL-6
−0.17 (−0.46, 0.12)
0.27
−0.24 (−0.54, 0.08)
0.14
IL-10
−0.03 (−0.16, 0.11)
0.69
0.19 (−0.55, 0.15)
0.28
TLR7-8
TNF-α
−0.35 (−0.84, 0.12)
0.64
−0.31 (−0.83, 0.20)
0.19
IL-6
−0.05 (−0.43, 0.28)
0.79
−0.18 (−0.59, 0.21)
0.89
IL-10
−0.85 (−1.47, −0.22)
0.008
−0.99 (−1.70, −0.30)
0.006
PHA
TNF-α
0.52 (−0.59, 1.73)
0.39
0.30 (−1.07, 1.55)
0.39
IL-6
0.52 (−0.55, 1.62)
0.33
0.30 (−1.02, 1.59)
0.67
IL-10
−0.36 (−0.34, 1.14)
0.35
0.08 (−0.80, 0.96)
0.87
Adjusted for gestational age, gender, birth body weight, mode of delivery, maternal allergy, and season of birth.
(b)
Univariate analysis (95% CI)
p
Multivariate analysis (95% CI)
p
TLR1-2
TNF-α
0.63 (−0.06, 1.50)
0.09
0.73 (−0.17, 1.64)
0.12
IL-6
0.21 (−0.63, 1.20)
0.67
0.51 (−0.77, 1.51)
0.51
IL-10
0.21 (−0.74, 1.11)
0.62
0.51 (−0.68, 1.50)
0.41
TLR3
TNF-α
0.77 (−0.01, 1.55)
0.06
0.63 (−0.27, 1.50)
0.16
IL-6
−0.13 (−0.83, 0.63)
0.73
0.18 (−0.86, 1.18)
0.71
IL-10
−0.17 (−0.67, 0.41)
0.54
−0.18 (−0.83, 0.50)
0.62
TLR4
TNF-α
0.20 (−0.22, 0.72)
0.41
0.21 (−0.41, 0.69)
0.70
IL-6
−0.05 (−0.38, 0.26)
0.77
0.01 (−0.39, 0.39)
0.96
IL-10
−0.03 (−0.16, 0.11)
0.69
0.19 (−0.55, 0.15)
0.28
TLR7-8
TNF-α
0.14 (−0.29, 0.58)
0.55
0.39 (−0.05, 0.85)
0.95
IL-6
0.14 (−0.36, 0.60)
0.60
−0.03 (−0.48, 0.47)
0.89
IL-10
−0.51 (−1.33, 0.23)
0.16
−0.49 (−1.64, 0.52)
0.40
PHA
TNF-α
0.94 (−0.06, 2.02)
0.78
0.61 (−0.45, 1.79)
0.29
IL-6
0.94 (−0.10, 2.00)
0.08
0.61 (−0.47, 1.74)
0.30
IL-10
0.56 (−0.27, 1.34)
14
0.47 (−0.56, 1.34)
0.30
Adjusted for gestational age, gender, birth body weight, mode of delivery, maternal allergy, and season of birth.
