Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis

Figure 3

Apoptosis through death receptors: a signaling pathway in TLE(HS). This pathway was generated by the IPA software, based on 10 of the 15 upregulated genes (cutoff 2.0-fold change; see Table 1) in hippocampal tissues from TLE(HS) patients () compared to post mortem controls (). The biological relationship between two genes, represented as nodes, is shown as a line. Nodes with different shapes indicate different functional class. The pathway created did not include the following genes: NFKB2, NGFR, TNFSF10, TNFRSF10C, and TNFSF10D. The function “nervous relaxed” was used. A, activation; E, expression regulation; I, inhibition; L, proteolysis; LO, localization; M, biochemical modification; P, phosphorylation; PD, protein-DNA interaction; PP, protein-protein interaction; RB, regulation of binding; T, transcription; and TR, translocation.