IL-32: A Novel Pluripotent Inflammatory Interleukin, towards Gastric Inflammation, Gastric Cancer, and Chronic Rhino Sinusitis

Figure 3

Microbial infection induced expression of IL-32 results in gastric inflammation. Microbial infection (H. pylori) leads to the upregulation of cagPAI cluster of genes which through the activation of NF-κB pathway results in the synthesis of IL-32 and some other potent inflammatory cytokines (IL-1, IL-8, and TNF-α) that results in gastric inflammation. The resulting inflammation self-augments the activation of NF-κB pathway which further aggravates the situation.