ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells into Osteoblasts through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways under Inflammatory Microenvironment

Figure 4

ET-1 promoted differentiation of PDLSCs through ETR pathway. The effect of ET-1 on ETRA mRNA expression level increased with increasing treatment time, peaking at 21 d ((a) and (d)). A time-dependent increase in ETRA protein level was also observed ((b) through (f)). The stimulatory effects on ETRB mRNA and protein levels were detected. Each bar represents the mean ± standard deviation (). ; ; .