ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells into Osteoblasts through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways under Inflammatory Microenvironment

Figure 5

ET-1 promoted differentiation of PDLSCs through MAPKs pathway. RT-PCR showed no difference in ERK, JNK, and p38 after ET-1 treatment ((a) and (d)). Western Blot analysis indicated that exposure of the cells to ET-1 effectively increased the levels of phosphor-ERK1/2, phosphor-JNK, and phosphor-p38 without altering the total amounts of these proteins ((b), (c), (e), and (f)). Each bar represents the mean ± standard deviation (). ; ; .