ET-1 Promotes Differentiation of Periodontal Ligament Stem Cells into Osteoblasts through ETR, MAPK, and Wnt/β-Catenin Signaling Pathways under Inflammatory Microenvironment

Figure 6

ET-1 promoted differentiation of PDLSCs through Wnt/β-catenin pathway. Upregulation of Axin, APC, β-catenin, and TCF/LEF mRNA levels was observed (a). Western Blot analysis indicated that exposure of the cells to ET-1 effectively increased the levels of Axin, APC, β-catenin, TCF, and LEF, whereas it downregulated the phosphor-GSK3β ((b) and (c)). Each bar represents the mean ± standard deviation (). ; ; .

(a)

(b)

(c)