Effect of Interferon-γ on the Basal and the TNFα-Stimulated Secretion of CXCL8 in Thyroid Cancer Cell Lines Bearing Either the RET/PTC Rearrangement Or the BRAF V600e Mutation

Figure 1

IFNγ inhibits the secretion of CXCL8 in BCPAP cells. (a) IFNγ significantly and dose-dependently inhibits the basal CXCL8 secretion (ANOVA F: 22.75; ; post hoc analysis by Bonferroni: versus basal). (b) IFNγ significantly inhibits the TNFα-stimulated CXCL8 secretion (ANOVA F: 15.30; ; post hoc analysis by Bonferroni:   and   versus TNFα). The inhibitory effect of IFNγ is expressed as percentage of basal and TNFα-induced levels of CXCL8, which were estimated as 100%.

(a)

(b)