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Mediators of Inflammation
Volume 2016, Article ID 8907314, 7 pages
Clinical Study

The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations

1Faculty of Medicine, Department of Pulmonary Medicine, Bulent Ecevit University, 67600 Zonguldak, Turkey
2Faculty of Medicine, Department of Biochemistry Zonguldak, Bulent Ecevit University, 67600 Zonguldak, Turkey
3Faculty of Medicine, Department of Otolaryngology, Bulent Ecevit University, 67600 Zonguldak, Turkey
4Faculty of Medicine, Department of Biostatistics, Bulent Ecevit University, 67600 Zonguldak, Turkey

Received 14 September 2015; Revised 24 December 2015; Accepted 30 December 2015

Academic Editor: Fumio Tsuji

Copyright © 2016 Firat Uygur et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [ absorbance units (ABSU), ABSU, ]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations ( ABSU to ABSU, ). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment.