Tumor Necrosis Factor-Like Weak Inducer of Apoptosis Accelerates the Progression of Renal Fibrosis in Lupus Nephritis by Activating SMAD and p38 MAPK in TGF-β1 Signaling Pathway

Figure 2

The expression of TWEAK protein in the kidneys. Total lysates of kidneys were collected for Western blotting to measure TWEAK protein expression. The representative experiment was presented (a). The ratios of TWEAK/β-actin IOD were shown (b). Control: MRL/lpr mice treated with PBS; Control shRNA: MRL/lpr mice treated with LV-Control shRNA; TWEAK-shRNA: MRL/lpr mice treated with LV-TWEAK-shRNA; and MRL/MPJ: MRL/MPJ mice as normal control. The error bars represent the standard deviation. versus MRL/MPJ mice and versus control MRL/lpr mice.

(a)

(b)