Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress

Table 1

Serum and kidney tissue levels of interleukins among groups.

Parameters	HRs ()	DRs ()	CIN + DRs ()	MTDRs ()	MTCIN + DRs ()
Kidney tissue IL-33 (ng/g tissue)	3756 ± 184	7171 ± 194	8163 ± 325	5463 ± 373^¥	5910 ± 552^#
Kidney tissue IL-6 (ng/g tissue)	1495 ± 81	4400 ± 41	4589 ± 77	3552 ± 33^¥	4072 ± 86^#
Kidney tissue IL-1β (ng/g tissue)	3501 ± 26	4470 ± 64	5194 ± 304	4387 ± 32	4527 ± 151
Serum IL-33 (ng/dL)	101 ± 4.7	144 ± 2.1	150 ± 4.1	115 ± 2.3^¥	122 ± 2.8^#
Serum IL-6 (ng/dL)	106 ± 11.3	149 ± 7.9	226 ± 7.5	101 ± 4.4^¥	109 ± 6.5
Serum IL-1β (ng/dL)	27.9 ± 1.2	33.8 ± 3.3	46.1 ± 2.7	35.8 ± 6.0	32.7 ± 0.4
Serum creatinine (ng/dL)	20 ± 6	27 ± 4	43 ± 5	22 ± 3^¥	33 ± 5^#

HRs: healthy rats, DRs: diabetic rats, CIN + DRs: diabetic rats with contrast-induced nephropathy, MTDRs: melatonin-treated diabetic rats, and MTCIN + DRs: melatonin-treated diabetic rats with contrast-induced nephropathy.
: diabetic rats versus healthy rats, .
: diabetic rats with CIN versus healthy rats, .
¥: melatonin-treated diabetic rats versus diabetic rats, .
#: melatonin-treated diabetic rats with CIN versus diabetic rats with CIN, .