Intraplaque Expression of C-Reactive Protein Predicts Cardiovascular Events in Patients with Severe Atherosclerotic Carotid Artery Stenosis
Table 4
Correlation between intraplaque CRP and inflammatory biomarkers in upstream and downstream plaques.
Upstream
Downstream
CRP, % vs.
value
CRP, % vs.
value
Neutrophils/mm2
0.208
0.008
Neutrophils/mm2
0.087
0.275
Total collagen, %
0.063
0.430
Total collagen, %
−0.035
0.659
Collagen I, %
−0.008
0.918
Collagen I, %
−0.046
0.560
Collagen III, %
−0.138
0.082
Collagen III, %
−0.030
0.710
Smooth muscle cells, %
−0.315
<0.001
Smooth muscle cells, %
0.028
0.726
Total macrophages (CD68+)†, %
0.158
0.046
Total macrophages (CD68+)†, %
0.097
0.222
M‡1 subset (CD86+), %
0.113
0.151
M‡1 subset (CD86+), %
0.193
0.014
M1 subset (HLA-DR+), %
0.161
0.042
M1 subset (HLA-DR+), %
0.226
0.004
M2 subset (CD163+), %
0.031
0.694
M2 subset (CD163+), %
0.344
<0.001
Correlations were performed by Spearman’s rank correlation coefficient. CRP: high sensitivity c-reactive protein. †CD: cluster of differentiation. ‡M: macrophage. HLA-DR: human leukocyte antigen-antigen D related.
