Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice

Figure 2

Effects of UCP2 on LPS-induced inflammatory lung injury, pulmonary edema, and survival rate. Mice were pretreated with UCP2-Ad, control virus (UCP2-NC), or genipin following injected LPS or saline. (a) Lungs from each group were processed for histological examination after H&E staining (400x). (b) Lung injury score in each group (). (c) The ratio (). (d) Total protein concentrations in BALF. (e) Total cells number in BALF. (f) The levels of TNF-α, IL-1β, and IL-6 in the BALF were quantified by ELISA (). (g) The comparisons of survival rate in each group (). versus UCP2-NC + saline group, versus UCP2-NC + LPS group, and versus the UCP2-Ad + LPS group. Values are presented as means ± SEM.

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