Table of Contents Author Guidelines Submit a Manuscript
Mediators of Inflammation
Volume 2016, Article ID 9343460, 10 pages
http://dx.doi.org/10.1155/2016/9343460
Research Article

Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma

1Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
2Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China
3Faculty of Nursing Science, Suzuka University of Medical Science, Suzuka, Mie, Japan
4Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, Japan

Received 30 May 2016; Revised 26 July 2016; Accepted 4 August 2016

Academic Editor: Vladislav B. Volarevic

Copyright © 2016 Shumin Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. B. B. Aggarwal and B. Sung, “The relationship between inflammation and cancer is analogous to that between fuel and fire,” Oncology, vol. 25, no. 5, pp. 414–418, 2011. View at Google Scholar · View at Scopus
  2. G. Trinchieri, “Inflammation in cancer: a therapeutic target?” Oncology, vol. 25, no. 5, pp. 418–420, 2011. View at Google Scholar · View at Scopus
  3. S. Ohnishi, N. Ma, R. Thanan et al., “DNA damage in inflammation-related carcinogenesis and cancer stem cells,” Oxidative Medicine and Cellular Longevity, vol. 2013, Article ID 387014, 9 pages, 2013. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Kawanishi, Y. Hiraku, S. Pinlaor, and N. Ma, “Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis,” Biological Chemistry, vol. 387, no. 4, pp. 365–372, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. Y. Hiraku, “Formation of 8-nitroguanine, a nitrative DNA lesion, in inflammation-related carcinogenesis and its significance,” Environmental Health and Preventive Medicine, vol. 15, no. 2, pp. 63–72, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Petersson, “Nasopharyngeal carcinoma: a review,” Seminars in Diagnostic Pathology, vol. 32, no. 1, pp. 54–73, 2015. View at Publisher · View at Google Scholar · View at Scopus
  7. Q. Tao and A. T. C. Chan, “Nasopharyngeal carcinoma: molecular pathogenesis and therapeutic developments,” Expert Reviews in Molecular Medicine, vol. 9, no. 12, pp. 1–24, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. L. Chen, C.-S. Hu, X.-Z. Chen et al., “Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial,” The Lancet Oncology, vol. 13, no. 2, pp. 163–171, 2012. View at Publisher · View at Google Scholar · View at Scopus
  9. L.-Q. Tang, C.-F. Li, J. Li et al., “Establishment and validation of prognostic nomograms for endemic nasopharyngeal carcinoma,” Journal of the National Cancer Institute, vol. 108, no. 1, Article ID djv291, 2016. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Murata, R. Thanan, N. Ma, and S. Kawanishi, “Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis,” Journal of Biomedicine and Biotechnology, vol. 2012, Article ID 623019, 11 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. W.-H. Su, A. Hildesheim, and Y.-S. Chang, “Human leukocyte antigens and Epstein-Barr virus-associated nasopharyngeal carcinoma: old associations offer new clues into the role of immunity in infection-associated cancers,” Frontiers in Oncology, vol. 3, article 299, 2013. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Wang, Y. Mo, K. Midorikawa et al., “The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L,” Oncotarget, vol. 6, no. 34, pp. 35893–35907, 2015. View at Publisher · View at Google Scholar · View at Scopus
  13. S. Wang, X. Xiao, X. Zhou et al., “TFPI-2 is a putative tumor suppressor gene frequently inactivated by promoter hypermethylation in nasopharyngeal carcinoma,” BMC Cancer, vol. 10, article 617, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Ma, M. Kawanishi, Y. Hiraku et al., “Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression,” International Journal of Cancer, vol. 122, no. 11, pp. 2517–2525, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. T. Reya, S. J. Morrison, M. F. Clarke, and I. L. Weissman, “Stem cells, cancer, and cancer stem cells,” Nature, vol. 414, no. 6859, pp. 105–111, 2001. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Shipitsin and K. Polyak, “The cancer stem cell hypothesis: in search of definitions, markers, and relevance,” Laboratory Investigation, vol. 88, no. 5, pp. 459–463, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Douville, R. Beaulieu, and D. Balicki, “ALDH1 as a functional marker of cancer stem and progenitor cells,” Stem Cells and Development, vol. 18, no. 1, pp. 17–26, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Kuncová, M. Urban, and V. Mandys, “Expression of CD44s and CD44v6 in transitional cell carcinomas of the urinary bladder: comparison with tumour grade, proliferative activity and p53 immunoreactivity of tumour cells,” APMIS, vol. 115, no. 11, pp. 1194–1205, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. B. Lohberger, B. Rinner, N. Stuendl et al., “Aldehyde dehydrogenase 1, a potential marker for cancer stem cells in human sarcoma,” PLoS ONE, vol. 7, no. 8, Article ID e43664, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. Z. Madjd, B. Ramezani, S. Molanae, and M. Asadi-Lari, “High expression of stem cell marker ALDH1 is associated with reduced BRCA1 in invasive breast carcinomas,” Asian Pacific Journal of Cancer Prevention, vol. 13, no. 6, pp. 2973–2978, 2012. View at Publisher · View at Google Scholar · View at Scopus
  21. S. Salaria, A. Means, F. Revetta, K. Idrees, E. Liu, and C. Shi, “Expression of CD24, a stem cell marker, in pancreatic and small intestinal neuroendocrine tumors,” American Journal of Clinical Pathology, vol. 144, no. 4, pp. 642–648, 2015. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Todaro, M. Gaggianesi, V. Catalano et al., “CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis,” Cell Stem Cell, vol. 14, no. 3, pp. 342–356, 2014. View at Publisher · View at Google Scholar · View at Scopus
  23. L. Karran, M. Jones, G. Morley et al., “Expression of a B-cell marker, CD24, on nasopharyngeal carcinoma cells,” International Journal of Cancer, vol. 60, no. 4, pp. 562–566, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. C.-H. Yang, H.-L. Wang, Y.-S. Lin et al., “Identification of CD24 as a cancer stem cell marker in human nasopharyngeal carcinoma,” PLoS ONE, vol. 9, no. 6, Article ID e99412, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Kondo, N. Wakisaka, M. Muramatsu et al., “Epstein-barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines,” Journal of Virology, vol. 85, no. 21, pp. 11255–11264, 2011. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Qin, Y.-T. Yin, F.-J. Zheng et al., “WNT5A promotes stemness characteristics in nasopharyngeal carcinoma cells leading to metastasis and tumorigenesis,” Oncotarget, vol. 6, no. 12, pp. 10239–10252, 2015. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Cheng, A. K. L. Cheung, J. M. Y. Ko et al., “Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma,” BMC Cell Biology, vol. 14, article 44, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Yang, L. Li, Y. Ren et al., “Clinical significance of joint detection of CD44v6 and CD62P in nasopharyngeal carcinoma,” Onkologie, vol. 36, no. 11, pp. 629–634, 2013. View at Publisher · View at Google Scholar · View at Scopus
  29. C.-W. Fan, L. Wen, Z.-D. Qiang et al., “Prognostic significance of relevant markers of cancer stem cells in colorectal cancer—a meta analysis,” Hepato-Gastroenterology, vol. 59, no. 117, pp. 1421–1427, 2012. View at Google Scholar · View at Scopus
  30. M. Gaviraghi, P. Tunici, S. Valensin et al., “Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells,” Bioscience Reports, vol. 31, no. 1, pp. 45–55, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Wu, W. Luo, Q. Zhang et al., “Aldehyde dehydrogenase 1, a functional marker for identifying cancer stem cells in human nasopharyngeal carcinoma,” Cancer Letters, vol. 330, no. 2, pp. 181–189, 2013. View at Publisher · View at Google Scholar · View at Scopus
  32. W.-R. Luo, F. Gao, S.-Y. Li, and K.-T. Yao, “Tumour budding and the expression of cancer stem cell marker aldehyde dehydrogenase 1 in nasopharyngeal carcinoma,” Histopathology, vol. 61, no. 6, pp. 1072–1081, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. W.-R. Luo and K.-T. Yao, “Cancer stem cell characteristics, ALDH1 expression in the invasive front of nasopharyngeal carcinoma,” Virchows Archiv, vol. 464, no. 1, pp. 35–43, 2014. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Hou, W. He, Y. Li et al., “Increased expression of aldehyde dehydrogenase 1 A1 in nasopharyngeal carcinoma is associated with enhanced invasiveness,” European Archives of Oto-Rhino-Laryngology, vol. 271, no. 1, pp. 171–179, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Pinlaor, Y. Hiraku, N. Ma et al., “Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis,” Nitric Oxide, vol. 11, no. 2, pp. 175–183, 2004. View at Publisher · View at Google Scholar
  36. D. P. Huang, J. H. C. Ho, Y. F. Poon et al., “Establishment of a cell line (NPC/HK1) from a differentiated squamous carcinoma of the nasopharynx,” International Journal of Cancer, vol. 26, no. 2, pp. 127–132, 1980. View at Publisher · View at Google Scholar · View at Scopus
  37. H. M. Li, C. Man, Y. Jin et al., “Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase,” International Journal of Cancer, vol. 119, no. 7, pp. 1567–1576, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. N. J. Maitland and A. T. Collins, “Inflammation as the primary aetiological agent of human prostate cancer: a stem cell connection?” Journal of Cellular Biochemistry, vol. 105, no. 4, pp. 931–939, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. M. R. Alison, “Liver stem cells: implications for hepatocarcinogenesis,” Stem Cell Reviews, vol. 1, no. 3, pp. 253–260, 2005. View at Publisher · View at Google Scholar · View at Scopus
  40. Y.-J. Huang, B.-B. Zhang, N. Ma, M. Murata, A.-Z. Tang, and G.-W. Huang, “Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma,” Medical Oncology, vol. 28, no. 1, pp. 377–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. R. Thanan, S. Oikawa, Y. Hiraku et al., “Oxidative stress and its significant roles in neurodegenerative diseases and cancer,” International Journal of Molecular Sciences, vol. 16, no. 1, pp. 193–217, 2014. View at Publisher · View at Google Scholar · View at Scopus
  42. R. Thanan, M. Murata, N. Ma et al., “Nuclear localization of COX-2 in relation to the expression of stemness markers in urinary bladder cancer,” Mediators of Inflammation, vol. 2012, no. 8, Article ID 165879, 2012. View at Publisher · View at Google Scholar · View at Scopus
  43. R. Thanan, C. Pairojkul, S. Pinlaor et al., “Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis,” Free Radical Biology and Medicine, vol. 65, pp. 1464–1472, 2013. View at Publisher · View at Google Scholar · View at Scopus
  44. J. M. Rosen and C. T. Jordan, “The increasing complexity of the cancer stem cell paradigm,” Science, vol. 324, no. 5935, pp. 1670–1673, 2009. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Yaqin, L. Runhua, and Z. Fuxi, “Analyses of Bcl-2, Survivin, and CD44v6 expressions and human papillomavirus infection in cervical carcinomas,” Scandinavian Journal of Infectious Diseases, vol. 39, no. 5, pp. 441–448, 2007. View at Publisher · View at Google Scholar · View at Scopus
  46. J.-T. Navarro, J.-M. Ribera, M. Vaquero et al., “Increased serum levels of CD44s and CD44v6 in patients with AIDS-related non-Hodgkin's lymphoma,” AIDS, vol. 14, no. 10, pp. 1460–1461, 2000. View at Publisher · View at Google Scholar · View at Scopus
  47. D. Li, L. Zheng, L. Jin et al., “CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection,” Hepatology, vol. 50, no. 3, pp. 735–742, 2009. View at Publisher · View at Google Scholar · View at Scopus
  48. H. Sun, Y. Pan, R. Wu et al., “CD24 Ala57Val polymorphism is associated with spontaneous viral clearance in the HCV-infected Chinese population,” Liver International, vol. 35, no. 3, pp. 786–794, 2016. View at Publisher · View at Google Scholar · View at Scopus
  49. A. Matzke-Ogi, K. Jannasch, M. Shatirishvili et al., “Inhibition of tumor growth and metastasis in pancreatic cancer models by interference with CD44v6 signaling,” Gastroenterology, vol. 150, no. 2, pp. 513–525.e10, 2016. View at Publisher · View at Google Scholar
  50. H. Tomita, K. Tanaka, T. Tanaka, and A. Hara, “Aldehyde dehydrogenase 1A1 in stem cells and cancer,” Oncotarget, vol. 7, no. 10, pp. 11018–11032, 2016. View at Publisher · View at Google Scholar
  51. S. Shinohara, T. Hanagiri, A. Taira et al., “Immunohistochemical expression and serum levels of CD44 as prognostic indicators in patients with non-small cell lung cancer,” Oncology, vol. 90, no. 6, pp. 327–338, 2016. View at Google Scholar