Inflammation-Related DNA Damage and Cancer Stem Cell Markers in Nasopharyngeal Carcinoma
Table 1
IHC grades of biomarkers in nasopharynx samples.
8-Nitroguanine IHC grades
−
+
++
+++
++++
value
Biopsy
Nasopharyngitis (12)
4
6
2
0
0
NPC (26)
0
5
8
10
3
0.001
Array
Normal mucosa (12)
6
5
1
0
0
0.662
NPC (35)
1
3
10
8
13
0.000
0.135
CD44v6 IHC grades
−
+
++
+++
++++
value
Biopsy
Nasopharyngitis (11)
7
4
0
0
0
NPC (18)
0
2
3
5
8
0.002
Array
Normal mucosa (12)
11
1
0
0
0
0.262
NPC (35)
6
4
15
9
1
0.001
0.001
ALDH1A1 IHC grades
−
+
++
+++
++++
value
Biopsy
Nasopharyngitis (5)
2
2
1
0
0
NPC (16)
0
3
5
6
2
0.044
Array
Normal mucosa (12)
4
6
2
0
0
0.932
NPC (35)
0
3
11
11
10
0.000
0.514
CD24 IHC grades
−
+
++
+++
++++
value
Biopsy
Nasopharyngitis (9)
0
3
4
2
0
NPC (10)
0
3
2
5
0
0.386
Array
Normal mucosa (12)
2
7
3
0
0
0.143
NPC (35)
15
13
4
3
0
0.189
0.006
IHC grades were assigned to each specimen according to the grade of staining intensity as described in the Materials and Methods. values were calculated by the chi-square test when comparing NPC and non-cancer tissues (nasopharyngitis, normal mucosa) in each group (biopsy or array, left). Comparisons were also made between biopsy nasopharyngitis tissues and array normal mucosa (right upper) and between biopsy NPC and array NPC (right lower).
