Research Article

Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation

Table 2

Histological scoring system used in this study.

PointEpithelial damageInflammatory cell infiltration

0Normal morphologyNo infiltrate
1Loss of goblet cellsInfiltrate around crypt base
2Loss of goblet cells in large areasInfiltrate reaching the L. muscularis mucosae
3Loss of cryptsExtensive infiltration reaching the L. muscularis mucosae and thickening of the mucosa with abundant edema
4Loss of crypts in large areasInfiltration of the L. submucosa