Systemic and Local Administration of Antimicrobial and Cell Therapies to Prevent Methicillin-Resistant Staphylococcus epidermidis-Induced Femoral Nonunions in a Rat Model

Figure 5

Qualitative µCT imaging, isosurface, and semiquantitative osteomyelitis score. The representative panel shows µCT images on the day of explantation. (a, c, e, g, i) Sagittal, coronal, and axial planes. (b, d, f, h, j) 3D isosurface reconstruction is presented for the s-VANC, s-rBMSCs, l-VANC, l-rBMSCs, and PC groups. Symbols indicate cortical reaction (white arrows); medullary reaction (yellow arrow); and loss of cortical wall and osteolysis (asterisks). (k) Osteomyelitis grading score based on Odekerken’s scale is reported in the histogram. Comparisons among groups were analyzed with one-way ANOVA corrected with Bonferroni’s post hoc test. Statistical significance was () and (); , s-rBMSCs.