NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis

Figure 2

The imaging evaluations. (a) Images of the Normal mice. (A) Clinical imaging; (B) Micro-CT coronal imaging; (C) three-dimensional imaging; (E) MRI imaging. (b) Images of the CIA mice. (A) The clinical imaging showed four toes, palm and ankle swelling, and palm skin ulceration; (B) CIA mouse Micro-CT coronal imaging revealed cystic destruction at metacarpophalangeal joints; (C) three-dimensional Micro-CT imaging revealed bone thinning at the metacarpophalangeal and proximal interphalangeal joints; (E) there was significant signal enhancements at a large area of soft tissues surrounding the joints, as indicated by the arrows. In addition, there was visible signal enhancement at articular surface of the annular region, suggestive of synovitis and bone marrow edema.

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