NLRP3 Inflammasome Plays an Important Role in the Pathogenesis of Collagen-Induced Arthritis

Figure 3

Histopathological evaluation. (a) The Normal mice showed normal joint space at the interphalangeal joint, 1–3 synovial cell layers, and smooth articular cartilage surface. (b), (c) CIA mice showed diminished interphalangeal joint space and diffuse infiltration of inflammatory cells (square area); significant proliferation of synovial cells and synovial cells invasion into cartilage and bone (arrow); visible neovascularization at synovial hyperplasia areas and inflammatory cell infiltration at perivascular areas (ring area). Magnification (×200).

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