Acinetobacter baumannii Infection and IL-17 Mediated Immunity

Table 1

Genetic KO mice that are commercially available for studying A. baumannii infection.

Gene products	Th1 pathway	Th2 pathway	Th17 pathway	Tfh pathway
Signature cytokines	Ifng^−/− defective in IFN- production	Il4^−/− defective in IL-4 production	IL-17-GFP tracking IL-17A producing cells
	Il12a^−/− defective in Th1 differentiation	Il5^−/− defective in IL-5 production	Il17aCre fate mapping IL-17A producing cells
	Il12b^−/− defective in Th1 and Th17 differentiation	Il13^−/− defective in IL-13 production	Il22Cre fate mapping IL-22 producing cells
			Il12b^−/− defective in Th1 and Th17 differentiation
Cytokine/chemokine receptors	Ifngr^−/− defective in IFN- signaling	Il4ra^−/− defective in IL-4 and IL-13 signaling		Cxcr5^−/− defective in Tfh differentiation
Transcription factors	Tbx21^−/− defective in Th1 differentiation	Stat6^−/− defective in Th differentiation	Rorc^−/− defective in Th17 differentiation
	Stat4^−/− defective in Th1 differentiation