Simultaneous Inhibition of PGE2 and PGI2 Signals Is Necessary to Suppress Hyperalgesia in Rat Inflammatory Pain Models
Induction of prostanoids synthesis and inhibitory profile of compound A in rat peritoneal macrophages. (a) The production of PGE2, 6-keto , , and TXB2 with or without LPS treatment. (b) to (e) Dose-dependent effects of compound A on the production of PGE2 (b), 6-keto (c), (d), and TXB2 (e) in rat macrophages. (f) Dose-dependent effects of celecoxib on the production of PGE2, 6-keto , , and TXB2 in rat macrophages. Results are shown as the mean ± SD (in duplicate). A representative result from reproduced experiments is shown.