Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis
lincRNA-p21 is downregulated in TGF-β1-treated HSCs and human liver fibrosis. (a) The downregulation of lincRNA-p21 expression was dose-dependently induced by TGF-β1. LX-2 cells were treated with TGF-β1 (0, 5, 10, and 15 ng/mL) for 24 h. (b) The downregulation of lincRNA-p21 expression was time-dependently induced by TGF-β1. LX-2 cells were treated with TGF-β1 (5 ng/mL) for 0, 24, 48, and 72 h. (c) Expression of lincRNA-p21 in liver tissues of healthy controls () and cirrhotic patients (). Each value is the mean ± SD of three experiments. compared with the control.
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