Identification of a Novel lincRNA-p21-miR-181b-PTEN Signaling Cascade in Liver Fibrosis
The effect of lincRNA-p21 on PTEN expression is through competitively binding miR-181b. (a) Correlation between lincRNA-p21 level and miR-181b expression in liver tissue samples from cirrhotic patients () was subjected to Pearson correlation analysis. (b) Schematic diagram of the miR-181b binding site in the lincRNA-p21 based on RNA22 software. (c) Relative luciferase activities of luciferase reporters bearing wild-type or mutant lincRNA-p21 were analyzed 48 h following transfection with the indicated miR-181b mimics or miR-NC in LX-2 cells. Each value is the mean ± SD of three experiments. .
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