Apoptosis of Endothelial Cells by 13-HPODE Contributes to Impairment of Endothelial Barrier Integrity
Mean normalized endothelial resistance across time during media control () and 150 μM 13-HPODE () exposure is displayed in (a). Mean normalized resistance for 100 μM 13-HODE () exposure up to 6 hr is displayed in (b). Mean normalized resistance across time during media control () and 25 ng/mL LPS () is displayed in (c). Resistance of BMEC monolayer across time for each treatment group (control and 13-HPODE, or control and 13-HODE, or control and LPS) was normalized relative to time 0. Significance of differences in resistance across time between treatment groups was tested by a two-way repeated measures ANOVA and adjusted by Bonferroni’s multiple comparisons test. An asterisk () represents significance declared at .