Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

Figure 2

Amphetamine induces microgliosis in the striatum of WT and MK−/− mice. (a) Photomicrographs are from Iba-1-immunostained striatal sections of saline- (Sal-) or amphetamine- (Amph-) treated animals. (b) The graph represents quantification of data (mean ± SEM) obtained from the counts of Iba-1-positive cells in standardized areas of the striatum. Significant effects of the genotype (F_(1,10) = 4.597, ) and treatment (F_(1,10) = 46.12, ) were found. and versus Sal. Scale bar = 200 μm.

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