Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine

<div>LPS-induced astrocytosis in the striatum of WT and MK−/− mice. (a) Photomicrographs are from GFAP-immunostained striatal sections of saline- (Sal-) treated or 0.5 mg/kg lipopolysaccharide- (LPS-) treated animals. (b) The graph represents quantification of data (mean ± SEM) obtained from the counts of GFAP-positive cells in standardized areas of the striatum. Scale bar = 200 <i>μ</i>m. Magnified inset = 50 <i>μ</i>m.</div>

Mediators of Inflammation

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Figure 4: Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine 

Figure 4 | Midkine Is a Novel Regulator of Amphetamine-Induced Striatal Gliosis and Cognitive Impairment: Evidence for a Stimulus-Dependent Regulation of Neuroinflammation by Midkine 