Proportions of Proinflammatory Monocytes Are Important Predictors of Mortality Risk in Hemodialysis Patients
Table 3
The univariate Cox regression analysis results for death risk.
Outcome types
CVD
All causes
Covariates
HR
95% CI
value
HR
95% CI
value
CD16+ monocytes, %
Q1(≤3.5 y) versus Q2
0.45
0.05
3.96
0.469
0.92
0.27
3.09
0.888
Q1(>3.5 y) versus Q2
5.16
0.56
47.86
0.149
2.00
0.53
7.63
0.308
Q3 versus Q2
2.18
0.73
6.52
0.161
1.86
0.81
4.31
0.145
Q4 versus Q2
5.13
1.90
13.84
0.001
3.44
1.58
7.48
0.002
Sex, male versus female
0.96
0.51
1.79
0.888
0.91
0.54
1.53
0.72
Age, years
1.03
1.01
1.06
0.011
1.04
1.02
1.06
<0.001
HD vintage, years
0.97
0.9
1.04
0.42
0.95
0.89
1.01
0.132
DM, yes versus no
2.18
1.12
4.25
0.021
1.87
1.09
3.2
0.023
Hypertension, yes versus no
3.14
1.23
8.04
0.017
2.16
1.09
4.27
0.027
Preexisting CAD, yes versus no
7.99
3.63
17.59
<0.001
5.66
3.11
10.3
<0.001
Preexisting CeVD, yes versus no
2.11
1.04
4.29
0.038
2.05
1.14
3.67
0.016
BMI, kg/m2
1.03
0.94
1.12
0.535
0.98
0.91
1.05
0.547
WBC, 103/μl
1.16
0.97
1.4
0.112
1.13
0.97
1.32
0.113
Monocyte,103/μl
1.06
0.87
1.28
0.558
1.05
0.89
1.23
0.583
HsCRP, mg/l
1.49
1.15
1.91
0.002
1.38
1.12
1.68
0.002
FBS, mg/dl
1.01
1
1.01
0.019
1.01
1
1.01
0.01
rHDL
4.98
0.31
80.71
0.259
4.95
0.5
48.94
0.172
cHDL, mg/dl
4.98
0.31
80.71
0.259
4.95
0.5
48.94
0.172
HbA1c, %
1.26
1.05
1.52
0.015
1.21
1.04
1.42
0.015
P, mg/dl
1.06
0.84
1.34
0.606
1.01
0.83
1.22
0.945
SBP, mmHg
1.01
1
1.03
0.171
1.01
1
1.02
0.181
DBP, mmHg
1.01
0.98
1.05
0.43
1.01
0.98
1.04
0.521
AbsoMono, cells/μl
1
1
1
0.121
1
1
1
0.127
PLT, 103/μl
1
1
1.01
0.042
1
1
1.01
0.133
Ferritin, μg/dl
1
1
1
0.155
1
1
1
0.761
TG, mg/dl
1
1
1
0.675
1
1
1
0.334
HDL, mg/dl
1
0.98
1.02
0.978
1
0.98
1.01
0.84
Cholesterol, mg/dl
0.99
0.98
1
0.121
0.99
0.98
1
0.029
rTG
0.86
0.44
1.68
0.654
0.82
0.46
1.43
0.48
Hb, g/dl
0.89
0.7
1.13
0.348
0.92
0.76
1.12
0.405
Albumin, g/dl
0.23
0.06
0.85
0.028
0.13
0.04
0.41
<0.001
BUN, mg/dl
1
0.97
1.02
0.802
0.99
0.97
1.01
0.165
Cr, mg/dl
0.83
0.71
0.97
0.019
0.77
0.67
0.88
<0.001
UA, mg/dl
0.89
0.72
1.1
0.274
0.86
0.73
1.01
0.073
Ca, mg/dl
0.97
0.8
1.17
0.734
0.96
0.76
1.21
0.732
Note: the abbreviations are the same as those denoted in Table 1. Q1, Q2, Q3, and Q4 denoted the four ascending classes of the categorical variable which was derived from categorizing each covariate by its three quartiles. The values of the three quartiles were listed in Table 1. Rows indicated as Q1(≤3.5 y) versus Q2 and Q1(>3.5 y) versus Q2 listed the time-varying effect of CD16+ monocytes below the lowest quartile for follow-up time before and after 3.5 years. indicates values of less than 0.05.
