Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS

Figure 5

Anti-inflammatory effect of PAO on carrageenan-induced paw edema in mice. Indo: indomethacin (10 mg/kg); PAO-L: low dose of PAO (10 mg/kg); PAO-M: medium dose of PAO (20 mg/kg); PAO-H: high dose of PAO (40 mg/kg). (a) Paw edema degree was represented as the ratio of the paw volume variation between basal volume (0 h) and different time interval (1, 2, 3, 4, 5, and 6 h) volumes after carrageenan treatment. (b) Inhibition of paw edema (%) was represented as the paw volume difference between the vehicle group and the administration groups. Data were expressed as means ± SEM. (), , , and versus the vehicle group.

(a)

(b)