Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS

Figure 8

Effect of PAO on the protein and mRNA expressions of COX-2 and iNOS in carrageenan-induced mouse paw. Indo: indomethacin (10 mg/kg); PAO-L: low dose of PAO (10 mg/kg); PAO-M: medium dose of PAO (20 mg/kg); PAO-H: high dose of PAO (40 mg/kg). (a) Protein expression of COX-2 and iNOS was measured by Western blot analysis. β-Actin was used as a loading control. (b) Effect of PAO on COX-2 and iNOS mRNA expression. Total RNA was isolated and analyzed for mRNA expression via RT-PCR. Data were expressed as means ± SEM. (), ^### versus the intact group. , , and versus the vehicle group.

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