Patchoulene Epoxide Isolated from Patchouli Oil Suppresses Acute Inflammation through Inhibition of NF-κB and Downregulation of COX-2/iNOS

Figure 9

Effect of PAO on the expressions of NF-κB pathway-related proteins in carrageenan-induced mouse paw. Indo: indomethacin (10 mg/kg); PAO-L: low dose of PAO (10 mg/kg); PAO-M: medium dose of PAO (20 mg/kg); PAO-H: high dose of PAO (40 mg/kg). Protein expression of p-IKKβ, IKKβ, p-IκBα, IκBα, and NF-κB (p50 and p65) was measured by Western blot analysis. β-Actin and H3 were used as loading controls. Data were expressed as means ± SEM. (), ^### versus the intact group. , and versus the vehicle group.

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