ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes

Figure 1

ZNF395 affects IFNα-mediated gene expression in keratinocytes. (a) Hierarchical clustering of transcriptome analysis of IFNα treated RTS3b cells, transfected with pooled siRNAs against ZNF395 (2, right) or control siRNA (1, left) in triplicate, using Affymetrix Hu Gene Chips. The gene clusters are shown on the right. In total, 156 genes were differentially expressed (-fold, ). (b) Venn diagram. Among the differentially expressed genes 54 were IFN-regulated genes, with 25 genes being upregulated and 29 genes being repressed by ZNF395. The Venn diagram shows the number of type I, type II, and type III interferon regulated genes that are affected by ZNF395 in IFNα treated RTS3b cells, as proposed by the Interferome database.

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