ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes

Figure 7

Schematic illustration of the regulation of ZNF395 within the immune response. Active IKK phosphorylates ZNF395, which allows ZNF395 to activate transcription of immune response involved genes. Phosphorylated ZNF395 is a target of the F-box protein β-TRCP, which is a subunit of the E3 ubiquitin ligase, the SCF (Skp1-Cullin-F-box) complex. β-TRCP directs the conjugation of ubiquitin to ZNF395 leading to its proteasomal degradation, thus keeping the transcriptional activity of ZNF395 low.