Research Article

ZNF395 Is an Activator of a Subset of IFN-Stimulated Genes

Table 2

List of known ISGs which depend for their full activation by IFNα on ZNF395, identified in RTS3b keratinocytes by microarray.

Fold change ANOVA value Gene symbolDescriptionType of IFN

7.750.008142CXCL10Chemokine (C-X-C motif) ligand 10I/II
6.520.000568UBE2D1Ubiquitin-conjugating enzyme E2D 1I
4.660.003393INHBAInhibin, beta AI
3.090.003036TMEM27Transmembrane protein 27II
2.860.000032SYCP2Synaptonemal complex protein 2I
2.750.007082CYP4F2Cytochrome P450, family 4, subfamily F, polypeptide 2, cytochrome P450, family 4, subfamily F, polypeptide 3III
2.670.000225CXCL11Chemokine (C-X-C motif) ligand 11I/II
2.640.000495IFIT2Interferon-induced protein with tetratricopeptide repeats 2I/II/III
2.620.000714IFIT1Interferon-induced protein with tetratricopeptide repeats 1I/II/III
2.360.001185H19H19, imprinted maternally expressed transcript (non-protein coding)II
2.330.000555TRIM22Tripartite motif containing 22I/II
2,330.0059C4orf32Chromosome 4 open reading frame 32I
2,290.001631CREBL2cAMP responsive element binding protein-like 2I
2.290.001CMPK2Cytidine monophosphate (UMP-CMP) kinase 2, mitochondrialI
2.230.00487CINPCyclin-dependent kinase 2 interacting proteinII
2.220.004045ITGB4Integrin, beta 4II
2.190.009825ZNF702PZinc finger protein 702, pseudogeneI
2.160.005895HERC5HECT and RLD domain containing E3 ubiquitin protein ligase 5I/II
2.130.000467MT1FMetallothionein 1FI/II
2.120.001274PEG10Paternally expressed 10II
2.10.000303AMIGO2Adhesion molecule with Ig-like domain 2II
2.10.008103MX2Myxovirus (influenza virus) resistance 2 (mouse)I/II
2.090.000294OPTNOptineurinI/II
2.080.000117ISG15ISG15 ubiquitin-like modifierI/II/III
2.030.000341ITGB3Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)I/II

Given are the fold changes (linear) siControl versus siZNF395 and the ANOVA value siControl versus siZNF395. The results are from three replicates. The type of IFN involved in regulation of the respective ISG is derived from the Interferome database (http://www.interferome.org/interferome/home.jspx; v2.01).