Endogenous IL-33 Deficiency Exacerbates Liver Injury and Increases Hepatic Influx of Neutrophils in Acute Murine Viral Hepatitis

Figure 2

Liver injury and survival curve of WT and IL-33 KO mice following L2-MHV3 infection. (a) Comparison of AST and (b) ALT level in sera of WT or IL-33 KO mice infected with L2-MHV3 at 48 h ( WT versus IL-33 KO) or 72 h ( WT versus IL-33 KO). (c) Liver sections of WT and IL-33 KO mice at 48 h and 72 h L2-MHV3 PI stained with H&E for histopathology to visualize zone of liver injury (dotted line in black). (d) Weight loss quantification in WT and IL-33 KO after 48 h ( WT versus 47 IL-33 KO) or 72 h ( WT versus IL-33 KO) of L2-MHV3 infection. (e) Survival curve of WT () or IL-33 KO () mice after L2-MHV3 infection. Statistical analyses were performed according to the Mann–Whitney U test. ; . symbolizes the significant difference between WT and IL-33 KO mice, whereas $ symbolizes the significant difference between two conditions in the same background mice.

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