CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

Figure 1

Effect of CpG-A and CpG-B on EAE. (a) Mice were i.p. treated with of CpG-A, CpG-B, or PBS on days 1, 3, and 5 p.i. Data are mean ± sem of daily scores, in one experiment representative of three independent experiments with mice per group. , (Mann–Whitney test). (b) Intraperitoneal treatment with CpG-A reduced EAE maximal and cumulative scores and delayed the onset (d) in C57BL/6 mice when compared to PBS-treated mice. Depicted are the means ± sem from three separate experiments ( per group). , by Kruskal-Wallis test followed by dunnett’s test as post hoc. .

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