CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

Figure 4

CpG-A treatment promotes regulatory cytokine responses. ELISA analysis of IFN-γ (a), IL-17 (b), and IL-10 (c) production from culture supernatants after MOG35–55 (25 μg/ml) stimulation of CNS-infiltrating cells or splenocytes from PBS- or CpG-A-treated mice at the peak of disease. Results shown are means ± sem from three independent EAE experiments. ; , two-tailed Mann–Whitney test.

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