Nuclear Factor of Activated T Cells and Cytokines Gene Expression of the T Cells in AIDS Patients with Immune Reconstitution Inflammatory Syndrome during Highly Active Antiretroviral Therapy

Figure 1

NFAT and cytokine gene relative expression levels compared before and after HAART in the immune reconstitution inflammatory syndrome (IRIS) and non-IRIS groups of AIDS patients. (a) NFAT expression in IRIS groups before and after HAART; NFAT1 expression from low to high after HAART; the relative expression of mRNA for NFAT1 gene to GAPDH after HAART was 3.002-fold higher as compared to that before HAART. (b) Cytokine gene expression in IRIS groups before and after HAART; IL-1β, IL-6, IL-8, and TNF-α expression from low to high; TNF-α gene expression also increased in non-IRIS group after HAART;the gene expressions after HAART were higher than those before treatment.

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