MCL Plays an Anti-Inflammatory Role in Mycobacterium tuberculosis-Induced Immune Response by Inhibiting NF-κB and NLRP3 Inflammasome Activation

Figure 3

MCL inhibits Mtb-induced NLRP3 production. Raw264.7 cells (1 × 10⁶/well) were seeded in 6-well plates overnight and with H37Ra infection as mentioned before, and cells were then treated with MCL at the concentration (5, 10, and 20 μM) for 12 hr. (a) The protein expression of NLRP3 was detected by Western blot, and β-actin was used as an internal control. (b) The bar graphs showed the statistical results for NLRP3 expression. Data are presented as mean ± SD in at least three independent experiments, .

(a)

(b)