The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa

Table 2

Comparison of inflammatory serum marker levels among healthy controls and patients with hidradenitis suppurativa, and the results of statistical assessments.

Cytokine levels (pg mL^−1); CRP (mg L^−1); ESR (mm hour^−1), mean ± SD (median)
	Healthy controls	Hidradenitis suppurativa	value^a
IL-1β	0.4 ± 0.8 (0.13)	0.9 ± 2.9 (0.00)	0.801
IL-6	0.6 ± 1.3 (0.00)	6.2 ± 10.7 (3.00)	0.001
IL-8	36.3 ± 73.9 (12.60)	27.9 ± 62.3 (13.62)	0.442
IL-10	3.3 ± 5.8 (0.97)	3.4 ± 9.2 (0.64)	0.979
IL-12p70	0.6 ± 1.9 (0.01)	3.4 ± 12.1 (0.00)	0.427
IL-17A	0.3 ± 0.6 (0.00)	5.6 ± 12.1 (0.00)	0.147
IL-22	0.0 ± 0.1 (0.00)	8.8 ± 25.6 (0.00)	0.950
IL-23	1.0 ± 2.5 (0.09)	0.9 ± 3.6 (0.00)	0.014
sTNF-RI	325.9 ± 507.1 (145.81)	879.8 ± 1914.7 (504.39)	<0.001
sTNF-RII	527.4 ± 266.9 (438.65)	927.9 ± 722.6 (507.19)	0.053
CRP	1.2 ± 2.1 (0.55)	13.4 ± 19.2 (7.00)	<0.001
ESR	10.2 ± 5.5 (9.50)	29.5 ± 23.9 (23.00)	<0.001

IL: interleukin; sTNF-RI: soluble TNF receptor I; sTNF-RII: soluble TNF receptor II; CRP: C-reactive protein; ESR: level erythrocyte sedimentation rate. ^aMann–Whitney U test between healthy controls and patients with hidradenitis suppurativa. .