The Clinical Significance of Increased Serum Proinflammatory Cytokines, C-Reactive Protein, and Erythrocyte Sedimentation Rate in Patients with Hidradenitis Suppurativa

Table 3

Comparison of inflammatory serum marker levels among healthy controls and patients with hidradenitis suppurativa according to clinical inflammatory activity based on their HS-PGA scores.

Cytokine levels (pg mL^−1); CRP (mg L^−1); ESR (mm hour^−1), mean ± SD (median)
	Healthy controls	Low inflammatory activity	Moderate inflammatory activity	High inflammatory activity	value^a
IL-1β	0.4 ± 0.8 (0.13)	0.4 ± 1.4 (0.00)	1.1 ± 3.2 (0.39)	1.3 ± 3.5 (0.19)	0.022
IL-6	0.6 ± 1.3 (0.00)	1.8 ± 3.9 (0.00)	4.6 ± 7.2 (3.38)	15.4 ± 16.3 (10.65)	<0.001
IL-8	36.3 ± 73.9 (12.60)	21.7 ± 70.4 (4.13)	17.6 ± 16.2 (17.89)	57.1 ± 97.3 (26.24)	0.003
IL-10	3.3 ± 5.8 (0.97)	0.7 ± 0.7 (0.46)	3.2 ± 5.7 (1.63)	7.5 ± 17.0 (2.82)	0.032
IL-12p70	0.6 ± 1.9 (0.01)	0.6 ± 2.2 (0.00)	4.2 ± 10.8 (0.15)	6.6 ± 19.9 (1.20)	0.022
IL-17A	0.3 ± 0.6 (0.00)	1.4 ± 5.2 (0.00)	6.4 ± 13.6 (0.40)	9.1 ± 16.8 (2.97)	0.001
IL-22	0.0 ± 0.1 (0.00)	12.9 ± 33.7 (0.00)	9.5 ± 25.3 (0.00)	1.9 ± 7.6 (0.00)	0.904
IL-23	1.0 ± 2.5 (0.09)	0.1 ± 0.3 (0.00)	0.9 ± 3.2 (0.00)	1.7 ± 6.0 (0.00)	0.026
sTNF-RI	325.9 ± 507.1 (145.81)	746.0 ± 634.2 (645.27)	1000.3 ± 2714.8 (390.42)	804.8 ± 689.2 (577.87)	<0.001
sTNF-RII	527.4 ± 266.9 (438.65)	491.4 ± 380.2 (368.32)	1017.1 ± 583.3 (1077.75)	1309.0 ± 1017.6 (1096.81)	<0.001
CRP	1.2 ± 2.1 (0.55)	4.8 ± 5.8 (2.25)	9.6 ± 9.8 (7.00)	32.2 ± 30.5 (22.00)	<0.001
ESR	10.2 ± 5.5 (9.50)	15.3 ± 12.3 (12.50)	25.2 ± 13.2 (23.00)	56.7 ± 30.6 (55.00)	<0.001

HS-PGA: Hidradenitis Suppurativa-Physician Global Assessment; IL: interleukin; CRP: C-reactive protein; sTNF-RI: soluble TNF receptor I; sTNF-RII: soluble TNF receptor II; ESR: level erythrocyte sedimentation rate. ^aKruskal-Wallis test comparing the circulating levels of inflammatory cytokines among the healthy controls and patients with hidradenitis suppurativa according to clinical inflammatory activity. .