Neutral Sphingomyelinase Behaviour in Hippocampus Neuroinflammation of MPTP-Induced Mouse Model of Parkinson’s Disease and in Embryonic Hippocampal Cells

Figure 1

Hippocampus of untreated (control) or MPTP-treated (experimental) mice. The samples were treated as reported in Material and Methods. (c) DAPI fluorescence image of the dentate gyrus of the hippocampus (10x magnification); in the square, detail enlarged in the images of CTR (control) and Treated (experimental). (a, d) iNOS and (b, e) nSMase (100x magnification oil immersion) immunofluorescence. The images represent the merged signals with DAPI signals (blue) in the nuclei and immunolabelling with anti-iNOS or anti-nSMase (red).