Buprenorphine Alters Inflammatory and Oxidative Stress Molecular Markers in Arthritis

Figure 5

Correlation analyses of gene expression of oxidative stress markers with pain scores in the human cohort. Baseline blood samples were collected in PAXgene tubes from 18 DMARD-naïve early RA subjects and were used to isolate RNA and determine gene expression by qRT-PCR. Each circle in the graph represents the ∆Ct values of individual samples after normalization with 18s RNA expression. Spearman correlation analysis was used to determine the correlation between pain VAS and specific gene expression. A value of <0.05 was considered to be statistically significant.