Statins Reduce Lipopolysaccharide-Induced Cytokine and Inflammatory Mediator Release in an In Vitro Model of Microglial-Like Cells

Figure 3

Statin-induced changes in (a) DCF fluorescence, as a measure of global ROS production, and (b) DAF fluorescence, as a measure of nitric oxide release, in LPS-activated dTHP-1 cells. Cells were pretreated for 24 h with one of the six statins (0–100 μM) prior to receiving a 24 h LPS stimuli, after which time DAF and DCF fluorescence were measured. Statin-treated data is represented as mean + SD; vehicle control (0 μM) is represented as mean + SEM. All values represent the results from three independent experiments. Statin treatment versus LPS only.

(a)

(b)